Treatment of ischemias by administration of 2,N.sup.6 -substituted adenosines

A compound of formula I ##STR11## wherein X is amino, C.sub.1-6 -alkylamino, di-C.sub.1-6 -alkylamino;

• R.sup.1 and R.sup.4 together form a cyclobutyl, cyclopentyl or cyclohexyl ring;
• Y is O, S, SO.sub.2 or N-alkyl, wherein alkyl is C.sub.2 or larger;
• R.sup.5 is a group of formula XI:
• ##STR12## wherein A is NH, O or S;
• B is CH or N;
• C is CH or N;
• and the group is substituted with R.sup.8 which is H, phenyl, C.sub.1-6 -alkyl, trifluoromethyl, amino, hydroxy, C.sub.1-6 -alkoxy, cyano or halogen;
• R.sup.6 is hydrogen, benzoyl or C.sub.1-6 -alkanoyl and
• R.sup.7 is hydrogen, benzoyl or C.sub.1-6 -alkanoyl;
• or
• a pharmaceutically acceptable salt thereof.

A compound of formula I ##STR13## wherein X is amino, C.sub.1-6 -alkylamino, di-C.sub.1-6 -alkylamino;

• R.sup.1 is H, straight or branched C.sub.1-6 -alkyl or trifluoromethyl;
• R.sup.4 is H or straight or branched C.sub.1-6 -alkyl;
• Y is O, S, or SO.sub.2 ;
• R.sup.5 is a group of formula XI:
• ##STR14## wherein A is NH, O or S;
• B is CH or N;
• C is CH or N;
• and the group is substituted with R.sup.8 which is H, phenyl, C.sub.1-6 -alkyl, trifluoromethyl, amino, hydroxy, C.sub.1-6 -alkoxy, cyano or halogen;
• R.sup.6 is hydrogen, benzoyl or C.sub.1-6 -alkanoyl and
• R.sup.7 is hydrogen, benzoyl or C.sub.1-6 -alkanoyl;
• or
• a pharmaceutically acceptable salt thereof.