Cyclic bridged analogs of .alpha.-MSH and methods thereof
AssigneeCompetitive Technologies, Inc.
InventorsMac E. Hadley, Victor J. Hruby, Shubh D. Sharma
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Abstract
A novel class of cyclic bridged analogs of .alpha.-MSH are described herein. With the described analogs, when administered in pharmaceutical compositions, it is now possible to achieve normalization of hypopigmentation dysfunctions and to achieve darkening of the skin in the total absence of sun or UV light irradiation.
Claims18
A method of stimulating melanocytes in vertebrates to cause the darkening of said vertebrate's skin coloration without the need to expose said skin to sunlight or UV light irradiation which comprises administering to said vertebrate at least one cyclic analogue of .alpha.-MSH selected from the group consisting of:
- ##STR22##
A cyclic analogue of alpha-MSH selected from the group consisting of:
- ##STR23##
Dependencies are inferred from the claim text.