Human papilloma virus inhibition by a hairpin ribozyme
AssigneesNorthern Illinois University, The United States of America as represented by the Department of Health and Human Services
InventorsArnold Hampel, Joseph DiPaolo, Andrew M. Siwkowski, Scott C. Galasinski
Life of this patent
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Abstract
Synthetic catalytic RNAs, i.e. ribozyme, including a hairpin portion, binding sites for binding to a human papilloma virus after viral base 419 and 434, respectively, and cleavage sites for cleaving the virus at the binding sites have been constructed.
Claims8
A synthetic hairpin ribozyme which binds to and cleaves a target site in a human papilloma virus transcript, said target site selected from the group consisting of target sites represented by:
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A method of constructing a ribozyme to cleave a human papilloma virus transcript comprising the step of constructing a hairpin ribozyme wherein a binding site on the ribozyme includes a sequence noncomplementary to the cleavage site on a human papilloma virus and a binding region complementary to the sequences on either side of the cleavage site where the binding regions are complementary to sequences selected from the group consisting of:
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Dependencies are inferred from the claim text.