Nanoparticles based on a polyoxyethelene and polyactic acid block copolymer
AssigneeRhone-Poulenc Rorer S.A.
InventorsGilles Spenlehauer, Didier Bazile, Michel Veillard, Christian Prud'Homme, Jean-Paul Michalon
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Abstract
The invention discloses nanoparticles offering an extended time before capture by the reticulo-endothelial system. Said particles are composed of an ethylene and/or propylene polyoxide polylactic copolymer optionally mixed with a polylactic polymer.
Claims9
Nanoparticles which evade the reticuloendothelial system, characterised in that they consist of a poly(ethylene oxide) and/or poly(propylene oxide) polylactic copolymer of units of formula:
- ##STR2## in which:
- R represents, in each of the alkylene oxide units, an identical or different group chosen from hydrogen or a methyl group,
- R' represents hydrogen or an alkyl group containing 1 to 4 carbon atoms,
- n is an integer between 20 and 1000,
- m is an integer between 10 and 1500.
Nanoparticles which evade the reticuloendothelial system, characterised in that they consist of a mixture of:
- a poly(ethylene oxide) and/or poly(propylene oxide) polylactic copolymer of units of formula (I) ##STR3## wherein R represents, in each of the alkylene oxide units, an identical or different group chosen from hydrogen or a methyl group;
- R' represents hydrogen or an alkyl group containing 1 to 4 carbon atoms;
- n is an integer between 20 and 1000;
- and m is an integer between 10 and 1500;
- and poly(lactic acid) polymer.
A pharmaceutical carrier comprising nanoparticles of poly(ethylene oxide) and/or poly(propylene oxide) polylactic copolymer containing a majority of units of Formula I:
- ##STR4## wherein R is, in each alkylene oxide units, and identical or different group chosen from hydrogen or a methyl group,
- R' is hydrogen or an alkyl containing 1 to 2 carbon atoms,
- n is an integer between 20 and 1000,
- m is an integer between 20 and 1500.
Dependencies are inferred from the claim text.