Encapsulated medicine
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTakehisa Hata, Fumio Shimojo, Kazutake Kado, Kyoko Ishii, Seiji Sawai
Life of this patent
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Abstract
This invention relates to an encapsulated pharmaceutical dosage form comprising a practically insoluble compound or salt and an intracapsular fluid, and/or a surfactant and/or cellulose derivative. It provides for increased oral absorption as compared with the conventional system because, on release of capsule contents from the capsule shell, the practically insoluble compound or salt undergoes diminution in crystal size.
Claims12
An encapsulated pharmaceutical dosage form, comprising a practically insoluble compound or salt thereof, an intracapsular fluid, and a compound selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose and carboxymethylcellulose, said dosage form forming microcrystals in situ having a mean particle diameter of no more than about 20.6 .mu.m.
An encapsulated pharmaceutical dosage form, comprising a practically insoluble compound or salt thereof, and intracapsular fluid, a surfactant and a compound selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose and carboxymethylcellulose.
Dependencies are inferred from the claim text.