Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug compositions
AssigneeCIBA Vision Corporation
InventorsAkira Yamada, Teresa H. Kuan, Ajay Vasudev Pandurangi
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Abstract
A package containing an aqueous drug composition containing an insoluble resin comprising benzalkonium salt units in an amount sufficient to inhibit growth of microbes in said aqueous drug solution. Typically, the insoluble resin is a polymer having repeating units of the formula: --CH.sub.2 --CH(Ar)!-- wherein Ar=a group of the formula: -Phe-CH.sub.2 --N.sup.+ (CH.sub.3).sub.2 R X.sup.- wherein R=long chain alkyl such as C.sub.8-18 alkyl, Phe=phenylene, and X.sup.- is a pharmaceutically acceptable counter anion such as Cl.sup.-.
Claims19
A package containing an aqueous drug composition comprising an insoluble resin, wherein said insoluble resin comprises benzalkonium units in an amount sufficient to inhibit growth of microbes in said aqueous drug composition, wherein said insoluble resin comprising benzalkonium units is a polymer containing repeating units of the formula:
- --CH.sub.2 --CH(Ar)!--
- wherein Ar=a group of the formula:
- -Phe-CH.sub.2 --N.sup.+ (CH.sub.3).sub.2 R X.sup.-
- wherein R=long chain alkyl, Phe=phenylene, and X.sup.- is a pharmaceutically acceptable counter anion.
Dependencies are inferred from the claim text.