Expression of recombinant proteins in attenuated bacteria
AssigneeGlaxo Wellcome Inc.
InventorsIan George Charles, Steven Neville Chatfield, Neil Fraser Fairweather
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Abstract
The invention concerns a method of prophylactically treating a host against infection by a microorganism, which method comprises administering to the host an attenuated Salmonella bacterium which contains a nirB promoter operably linked to a DNA sequence encoding a heterologous protein. The heterologous protein is expressed in the host and induces in the host an immune response against the microorganism.
Claims7
A method for prophylactically treating a host against infection by a microorganism, which method comprises administering to the host an attenuated Salmonella bacterium which contains a nirB promoter operably linked to a DNA sequence encoding a heterologous protein, wherein the heterologous protein is expressed in the host and induces in the host an immune response against the microorganism.
Dependencies are inferred from the claim text.