Method for the treatment of tumors with conjugated antibody A5B7 and a prodrug
AssigneeCancer Research Campaign Tech. Ltd. & Zeneca Ltd.
InventorsKenneth D. Bagshawe, Gordon T. Rogers, Surinder K. Sharma
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Abstract
A method for treatment of tumors to which antibody A5B7 binds is disclosed. A5B7 is a monoclonal antibody which binds to carcinoembryonic antigen. The method comprises administering to a host in need of such treatment an effective amount of a system which comprises a conjugate comprising: antibody A5B7 or a humanized version of A5B7 linked to an enzyme selected from the group consisting of carboxypeptidase G2 (CPG2), nitroreductase, a human enzyme, a non-human enzyme rendered non-immunogenic in man and a humanized catalytic antibody; and a prodrug convertible under the influence of the conjugate into a cytotoxic drug.
Claims24
A method of treatment of tumors to which antibody A5B7 binds, said method comprising administering to a host in need of such treatment a system which comprises:
- i) a conjugate comprising
- a) antibody A5B7 ;
- linked to
- b) an enzyme selected from the group consisting of carboxypeptidase G2 (CPG2) and nitroreductase;
- and,
- ii) a prodrug convertible under the influence of the conjugate into a cytotoxic drug.
A method of treatment of tumors to which antibody A5B7 binds, said method comprising administering to a host in need of such treatment a system which comprises:
- i) a conjugate of A5B7 antibody and carboxypeptidase G2 enzyme;
- and,
- ii) a prodrug convertible under the influence of the conjugate into a cytotoxic drug.
A method of treatment of tumors to which antibody A5B7 binds, said method comprising administering to a host in need of such treatment a system which comprises:
- i) a conjugate comprising
- a) antibody A5B7 ;
- linked to
- b) an enzyme selected from the group consisting of carboxypeptidase G2 (CPG2) and nitroreductase;
- and,
- ii) a mustard prodrug convertible under the influence of the conjugate into a cytotoxic drug.
A method of treatment of tumors to which antibody A5B7 binds, said method comprising administering to a host in need of such treatment a system which comprises:
- i) a conjugate of A5B7 antibody and carboxypeptidase G2 enzyme;
- and,
- ii) a mustard prodrug convertible under the influence of the conjugate into a cytotoxic drug.
A method of treatment of tumors to which antibody A5B7 binds, said method comprising administering to a host in need of such treatment a system which comprises:
- i) a humanized A5B7 antibody linked to a member of the group consisting of a human enzyme, a non-human enzyme rendered non-immunogenic in man and a humanized catalytic antibody;
- and,
- ii) a prodrug convertible under the influence of (i) into a cytotoxic drug.
Dependencies are inferred from the claim text.