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US 5,683,461 AGranted
Synthesis of reactive amorphous calcium phosphates
AssigneeEtex Corporation
InventorsDosuk D. Lee, Christian Rey, Maria Aiolova
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Abstract
The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37.degree. C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.
Claims12
An injectable paste comprising:
- a decarbonated amorphous calcium phosphate prepared by removing by thermal decomposition at least a portion of a carbonate component from a carbonated amorphous calcium phosphate;
- a second calcium phosphate, the second calcium phosphate and amorphous calcium phosphate present in a proportion to provide a Ca/P ratio characteristic of an apatitic calcium phosphate;
- and
- an amount of aqueous medium sufficient to provide a paste of a desired consistency,
- characterized in that when in a moist tissue environment and upon reaching body temperature (37.degree. C.), the paste hardens into a poorly crystalline hydroxyapatite without exothermic behavior.
2 more elements
A method of promoting bone growth, comprising:
- identifying a site requiring bone growth;
- applying to the site a paste comprising:
- a decarbonated amorphous calcium phosphate prepared by removing by thermal decomposition at least a portion of the carbonate component from a carbonated amorphous calcium phosphate;
- a second calcium phosphate, the second calcium phosphate and amorphous calcium phosphate present in a proportion to provide a Ca/P ratio characteristic of an apatitic calcium phosphate;
- and
- an amount of aqueous medium sufficient to provide a desired consistency;
- and allowing the paste to harden without exothermic behavior, whereby a poorly crystalline hydroxyapatite is formed.
4 more elements
Dependencies are inferred from the claim text.