Antibodies to IL-1.beta.
AssigneesNew England Med. Center Hospitals, Tufts College, Wellesley College, Mass. Inst. of Technology
InventorsPhilip E. Auron, Charles A. Dinarello, Andrew C. Webb, Alexander Rich, Sheldon M. Wolff
Life of this patent
Estimating the term…
Abstract
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. The subject invention further concerns antibodies that are immunoreactive with human IL-1.beta. proteins. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.
Claims5
An antibody preparation consisting essentially of antibodies produced by immunizing an animal with essentially pure human precursor IL-1.beta. or an immunogenic fragment thereof.
An antibody preparation which specifically binds with human precursor IL-1.beta. or an immunogenic fragment thereof.
Dependencies are inferred from the claim text.