Controlled release drug delivery device
AssigneeCiba-Geigy Corporation
InventorsLouis Savastano, James Carr, Elizabeth Quadros, Shailesh Shah, Satish Chaudra Khanna
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Abstract
A drug delivery device for delivering a drug either intermittently or to a pre-selected region of the gastro-intestinal tract, particularly to the colon, consists of an a solid core comprising an active agent coated with a delay jacket, then coated with a semi-permeable membrane which is optionally drilled to provide a release orifice, and then optionally further coated with an enteric material. The device delivers substantially all of the active agent to the targeted site.
Claims23
A drug delivery device which comprises:
- a) a solid core comprising a pharmaceutical or veterinary active agent;
- b) a substantially soluble delay jacket coated over the core through which the active agent can diffuse, the delay jacket comprising at least one component selected from the group consisting of a binder, an osmotic agent, and a lubricant;
- c) a semi-permeable membrane coated over the delay jacket and
- d) an additional layer of active agent.
A method of making an orally administrable active agent delivery device which comprises:
- a) forming a solid core comprising a pharmaceutical or veterinary active agent;
- b) coating said core with a substantially soluble delay jacket through which the active agent can diffuse, the delay jacket comprising at least one component selected from the group consisting of a binder, an osmotic agent, and a lubricant;
- c) coating said delay jacket with a semi-permeable membrane;
- and
- d) adding an additional layer of active agent, said additional layer of active agent being:
- i) between the delay jacket and the semi-permeable membrane;
- or
- ii) outside of the semi-permeable membrane.
A method of making an orally administrable active agent delivery device which comprises:
- a) forming a solid core comprising a pharmaceutical or veterinary active agent;
- b) coating said core with a substantially soluble delay jacket through which the active agent can diffuse, the delay jacket comprising at least one component selected from the group consisting of a binder, an osmotic agent, and a lubricant;
- c) coating said delay jacket with a semi-permeable membrane;
- d) coating said semi-permeable membrane with an enteric coating;
- and
- e) adding an additional layer of active agent, said additional layer of active agent being:
- i) between the delay jacket and semi-permeable membrane;
- ii) between the semi-permeable membrane and the enteric coating;
- or
- iii) outside of the enteric coating.
Dependencies are inferred from the claim text.