Back to results
US 5,681,273 AGranted
Systems and methods for predicting blood processing parameters
AssigneeBaxter International Inc.
InventorRichard I. Brown
Life of this patent
Estimating the term…
Abstract
Systems and methods predict a whole blood processing volume required to achieve a desired platelet yield based upon inputs of selected processing parameters.
Claims6
A blood processing system comprising:
- a separation device for separating whole blood into red blood cells and a plasma constituent,
- an inlet path including a pump for conveying whole blood from an individual donor into the separation device at a blood flow rate, Q.sub.b,
- a second path for adding an anticoagulant including a citrate concentration to the whole blood,
- an input to receive selected processing parameters including:
- a selected procedure time, t,
- a selected anticoagulant hematocrit for whole blood to be processed, H.sub.b,
- the blood flow rate Q.sub.b,
- a desired plasma collection volume, PPP.sub.GOAL,
- a system variable WB.sub.RES reflecting a residual volume of whole blood drawn but not processed,
- a processor coupled to the input that generates a whole blood processing volume, WBVol, as follows:
- ##EQU32## an output coupled to the processor for outputting WBVol, and a controller coupled to the inlet path pump to control Q.sub.b (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQb.sub.CIR, where:
- ##EQU33## where:
- CIR is a nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,
- AC is a selected anticoagulant ratio,
- Wgt is the individual donor's weight (in kg or equivalent), and
- CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).
13 more elements
A blood processing method for achieving a desired platelet yield comprising the steps of:
- inputting processing parameters including:
- a selected procedure time, t,
- a selected anticoagulated hematocrit for whole blood to be processed, H.sub.b,
- a selected blood flow rate Q.sub.b,
- desired plasma collection volume, PPP.sub.GOAL,
- a system variable WB.sub.RES reflecting a residual volume of whole blood retained after processing and not collected or returned,
- deriving a whole blood processing volume, WBVol, to achieve the desired platelet yield, based upon the selected processing parameters as follows:
- ##EQU34## outputting WBVol, conveying a volume of whole blood, taking into account WBVol, at the rate Q.sub.b from an individual donor into a separation device for separation into red blood cells and a plasma constituent,
- adding anticoagulant including a concentration of citrate to the whole blood, and
- controlling Qb (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQB.sub.CIR, where:
- ##EQU35## where:
- CIR is a nominal a-symptomatic citrate infusion rate (in mq/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,
- AC is a selected anticoagulant ratio,
- Wgt is the individual donor's weight (in kg or equivalent), and
- CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).
12 more elements
Dependencies are inferred from the claim text.