Oral immunization by transgenic plants
AssigneeWashington University
InventorsRoy Curtiss, III, Guy A. Cardineau
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Abstract
The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.
Claims26
A transgenic plant, comprising and expressing a DNA sequence coding for an antigen of a pathogenic microorganism or an antigenic determinant thereof, said antigen or antigenic determinant thereof eliciting a secretory immune response in a human or other animal upon oral administration of tissue of said plant.
A comparison suitable for eliciting a secretory immune response in a human or other animal which comprises:
- a transgenic plant or tissue obtained from a transgenic plant, said transgenic plant comprising and expressing a DNA sequence coding for an antigen of a pathogenic microorganism or an antigenic determinant thereof, said antigen or antigenic determinant being capable of eliciting a secretory immune response upon oral administration of said plant or plant tissue.
A transgenic plant which
- (a) expresses a DNA sequence coding for an antigen or antigenic determinant of a pathogenic microorganism, and
- (b) comprises plant tissue which after being orally administered to a human or other animal induces a secretory immune response to said antigen or antigenic determinant.
Dependencies are inferred from the claim text.