Reagants and methods for immobilized polymer synthesis and display
AssigneeAffymax Technologies N.V.
InventorChristopher P. Holmes
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Abstract
Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, .beta.-turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.
Claims11
A composition having the formula:
- A--B--L
- wherein A is a solid substrate,
- B is a bond or a derivatizing group selected from the group consisting of aminoalkyltrialkoxysilanes, hydroxylalkyltrialkoxysilanes, polyethyeleneglycols, polyethyleneimines, polyacrylamide, and polyvinylalcohol;
- and
- L is a photocleavable linking group having the formula ##STR29## wherein, R.sup.1 is methyl;
- R.sup.3 is methoxy;
- R.sup.2 and R.sup.4 are hydrogen;
- X.sup.21 is --OH, --NH.sub.2, --OP, and --NHP, wherein P is a suitable protecting group;
- and
- q is 1 or 3.
A composition comprising a plurality of beads wherein each of said beads further comprises a linker having the formula ##STR32## wherein, .sup.1 is methyl;
- R.sup.3 is methoxy;
- R.sup.2 and R.sup.4 are hydrogen
- X.sup.21 is --OH, --NH.sub.2, --OP, and --NHP, wherein P is a suitable protecting group;
- and
- q is 1 or 3.
Dependencies are inferred from the claim text.