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US 5,679,723 AGranted
Hard tissue bone cements and substitutes
AssigneeEthicon, Inc.
InventorsKevin Cooper, Chao C. Chen, Angelo Scopelianos
Life of this patent
Estimating the term…
Abstract
Absorbable/resorbable mixtures of aliphatic polyesters of poly(lactide), poly(glycolide), poly(trimethylene carbonate), poly(p-dioxanone) and poly(.epsilon.-caprolactone) and calcium containing bone regenerating compounds such as powdered, non-fibrous calcium phosphates are described. The composites when used to manufacture medical devices exhibit improved absorption characteristics and other physical properties.
Claims6
A method of conforming a medical device to a body structure, comprising:
- injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises:
- a liquid, low melt, injectable biocompatible composite, comprising:
- a) a first absorbable component comprising a polymer formed from aliphatic lactone monomers selected from the group consisting of p-dioxanone, trimethylene carbonate, .epsilon.-caprolactone, delta-valerolactone, beta-butyrolactone, epsilon-decalactone, 2,5-diketomorpholine, pivalolactone, alpha-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, gamma-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 1,4-dioxan-2-one, 6,8-dioxabicycloctane-7-one, and combinations thereof wherein said polymer has an inherent viscosity of about 0.05 to about 0.5 dL/g and,
- b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound is selected from the group consisting of mono-, di-, octa, .alpha.-tri-, .beta.-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and,
- implanting the device in the body structure.
2 more elements
A method of conforming a medical device to a body structure, comprising:
- injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises:
- a liquid, low melt, injectable biocompatible composite, comprising:
- a) a first absorbable component comprising a polymer selected from the group consisting of poly(p-dioxanone-co-glycolide), poly(trimethylene carbonate-co-glycolide), poly(.epsilon.-caprolactone-co-glycolide), poly(p-dioxanone-co-lactide), and poly(trimethylene carbonate-co-lactide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and
- b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, .alpha.-tri-, .beta.-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and,
- implanting the device in a body structure.
2 more elements
A method of conforming a medical device to a body structure, comprising:
- injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises:
- a liquid, low melt, injectable biocompatible composite, comprising:
- a) a first absorbable phase comprising a polymer selected from the group consisting of poly(p-dioxanone-co-glycolide), poly(trimethylene carbonate-co-glycolide), poly(.epsilon.-caprolactone-co-glycolide), poly(p-dioxanone-co-lactide), and poly(trimethylene carbonate-co-lactide), and blends thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and
- b) a second resorbable phase comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, .alpha.-tri-, .beta.-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof.
1 more element
A method of conforming a medical device to a body structure, comprising:
- injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises:
- a liquid, low melt biocompatible composite, comprising:
- a) a first absorbable component comprising a mixture of homopolymers selected from the group consisting of poly(p-dioxanone), poly(trimethylene carbonate), poly(.epsilon.-caprolactone) and poly(glycolide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and
- b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, .alpha.-tri-, .beta.-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and,
- implanting the device in the body structure.
2 more elements
A method of conforming a medical device to a body structure, comprising:
- injecting a medical device to effectively conform it to the contours of a body structure, wherein the device comprises:
- a liquid, low melt, injectable biocompatible composite, comprising:
- a) a first absorbable component comprising a mixture of homopolymers selected from the group consisting of poly(p-dioxanone), poly(trimethylene carbonate), poly(.epsilon.-caprolactone) and poly(lactide), and combinations thereof, and wherein said polymer has an inherent viscosity of about 0.05 dL/g to about 0.5 dL/g, and
- b) a second resorbable component comprising a hard tissue osteoconductive or osteoinductive calcium containing compound wherein the calcium containing, non-fibrous, powdered compound selected from the group consisting of mono-, di-, octa, .alpha.-tri-, .beta.-tri, and tetra-calcium phosphate, hydroxyapatite, fluorapatite, calcium sulfate, calcium fluoride, calcium oxide and combinations thereof and,
- implanting the device in the body structure.
2 more elements
Dependencies are inferred from the claim text.