Vaccines containing non-ionic surfactant vesicles
AssigneeProteus Molecular Design Limited
InventorsJames Alexander, James MacDonald Brewer
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Abstract
Non-ionic surfactant vesicles (NSIV) with entrapped antigen act as potent immunological adjuvants and can produce antibody titers of the same order of magnitude as those using Freund's Complete Adjuvant. The invention provides vaccines comprising such vesicles. Preferably non-ionic surfactants are glycerol esters particularly 1-monopalmitoyl glycerol. The vesicles may be administered by injection or via the mucosal route, oral administration being preferred.
Claims36
A vaccine comprising at least one antigen entrapped in non-ionic surfactant vesicles, wherein said vesicles enhance the immune response to said at least one antigen.
A vaccine for oral administration comprising at least one antigen entrapped in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A vaccine for mucosal administration comprising at least one antigen entrapped in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
An oral vaccine comprising at least one antigen entrapped in non-ionic surfactant vesicles in the form of a syrup or capsule wherein said vesicles enhance the immune response to said at least one antigen.
A method for preparing a vaccine comprising entrapping at least one antigen in non-ionic surfactant vesicles, wherein said vesicles enhance the immune response to said at least one antigen.
A method of formulating an antigen as an orally-active vaccine comprising entrapping said antigen in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said antigen.
A method of formulating at least one antigen to stimulate antibody production via the Th1 T lymphocyte pathway comprising entrapping said at least one antigen in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A method for potentiating the immunogenicity of at least one antigen to a level at least equal to that obtained by the use of Freund's Complete Adjuvant comprising entrapping said at least one antigen in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A method of potentiating the immunological response to at least one antigen in a subject comprising administering to said subject said at least one antigen entrapped in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A method of potentiating the immunological response to at least one antigen in a subject comprising orally administering to said subject said at least one antigen entrapped in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A method of stimulating cell mediated and/or humoral immunity in a subject in response to at least one antigen comprising administering to said subject said at least one antigen entrapped in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A method of stimulating antibody production via the Th1 T lymphocyte pathway in a subject in response to at least one antigen comprising administering to said subject said at least one antigen entrapped in non-ionic surfactant vesicles wherein said vesicles enhance the immune response to said at least one antigen.
A vaccine comprising at least one antigen entrapped in non-ionic surfactant vesicles, wherein said antigen alone elicits a weak immune response and said vesicles enhance the immune response to said at least one antigen.
A method for preparing a vaccine comprising entrapping at least one antigen in non-ionic surfactant vesicles, wherein said antigen alone elicits a weak immune response and said vesicles enhance the immune response to said at least one antigen.
Dependencies are inferred from the claim text.