Synthetic Haemophilus influenzae conjugate vaccine
AssigneeConnaught Laboratories Limited
InventorsPele Chong, Ali Kandil, Charles Sia, Michel Klein
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Abstract
Synthetic peptides have an amino acid sequence corresponding to at least one antigenic determinant of at least one protein, usually a structural protein, particularly the P1, P2 and P6 protein, of Haemophilus influenzae (Hi), particularly type b, and are used as is, in chimeric T-B form, in lipidated form, linked to a carrier molecule, particularly a synthetic PRP molecule and/or polymerized to form molecular aggregates, in vaccines against Hi.
Claims11
An immunogenic conjugate, comprising a synthetic peptide having an amino acid sequence which includes at least one immunodominant T-cell epitope of at least one other membrane protein (OMP) of Haemophilus influenzae linked to at least one synthetic B-cell epitope.
Dependencies are inferred from the claim text.