Fluorescent marker components and fluorescent probes
AssigneeDiatron Corporation
InventorPeter Olof Gustaf Arrhenuis
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Abstract
Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applications such as fluorescence immunoassays and in vivo imaging.
Claims47
A fluorescent probe which comprises a detectably labeled marker component linked to one member of a specific binding pair wherein said detectably marker component comprises a fluorophore moiety which is linked to one or more solubilizing polyoxyhydrocarbyl moieties and wherein said fluorescent probe has diminished non-specific binding to biological macromolecules compared with a fluorescent probe comprising said member of a specific binding pair linked to said fluorophore moiety, but not linked to said polyoxyhydrocarbyl moieties.
Dependencies are inferred from the claim text.