Anti-CD40 monoclonal antibodies capable of blocking B-cell activation
AssigneeChiron Corporation
InventorsMark de Boer, Leah B. Conroy
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Abstract
Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
Claims11
A monoclonal antibody or fragment thereof that is capable of specifically binding to a human CD40 antigen expressed on the surface of a normal human B cell, said monoclonal antibody or fragment being free of significant agonistic activity whereby when said monoclonal antibody or fragment binds to the CD40 antigen expressed on the surface of said normal human B cell, the growth or differentiation of said normal human B cell is inhibited.
A hybridoma capable of producing a monoclonal antibody having specificity for a CD40 antigen expressed on the surface of a normal human B cell, said monoclonal antibody being free of significant agonistic activity, whereby when said monoclonal antibody binds to said CD40 antigen expressed on the surface of said normal human B cell, the growth or differentiation of said normal human B cell is inhibited.
Dependencies are inferred from the claim text.