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AssigneeRhone Merieux, societe anonyme
InventorsJean-Christophe Francis Audonnet, Raphael Jean Darteil, Michel Albert Emile Riviere, Vladimir Zelnik, Louis Joseph Norman Ross
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Herpesviruses naturally deficient in gD, that is to say not expressing their gD gene in vitro or not possessing this gene, are transformed to express gD in vitro. This transformation by genetic recombination can consist in replacement of the natural promoter by another one or insertion of an expression cassette containing gD and a promoter. The invention also relates to these viruses incorporating a gene coding for an antigen of interest, to the vaccines obtained and to the methods of culture thus improved. The invention relates in particular to avian herpesviruses, especially MDV, and the VZV virus.
A herpesvirus naturally deficient in gD selected from the group consisting of serotypes 1, 2, 3 MDV virus and VZV virus, where said herpesvirus transformed to express a gD glycoprotein during its replication in vitro.
Recombinant serotype 1, 2 or 3 MDV herpesvirus genetically transformed to express gD outside the feature follicle during its replication in vivo.
Recombinant VZV herpesvirus genetically transformed to express gD during its replication in vivo.
Dependencies are inferred from the claim text.