Bovine herpesvirus type 1 deletion mutants and vaccines
AssigneeStichting Centraal Diergeneeskundig Instituut
InventorsFranciscus Antonius Maria Rijsewijk, Johannes Theodorus van Oirschot, Roger Kamiel Maes
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Abstract
A deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene and which may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene is disclosed. Recombinant nucleic acids which encode the gE-gene or a part thereof are also disclosed, in addition to vaccines and a method of treatment.
Claims9
A mutant of bovine herpesvirus type 1 (BHV-1) having a deletion of the glycoprotein gE-gene, wherein said deletion allows the mutant to be distinguished serologically from wild-type BHV-1.
A BHV-1 mutant having a deletion of the glycoprotein gE-gene, wherein said deletion allows said mutant to be distinguished serologically from wild-type BHV-1 by a process of discriminating between BHV-1 viruses having an intact gE-gene and BHV-1 viruses having a deletion of the gE-gene, said process comprising the step of examining whether nucleic acid of the virus reacts with gE specific probes or primers derived from the nucleotide sequence coding for gE.
A BHV-1 mutant having a deletion of the glycoprotein gE-gene, wherein said deletion allows said mutant to be distinguished serologically from wild-type BHV-1 by a process of discriminating between BHV-1 viruses expressing gE and BHV-1 viruses having a deletion of the gE-gene, said process comprising the step of examining whether the virus reacts with gE-specific antibodies raised against gE or against peptides derived from the amino acid sequence of gE.
Dependencies are inferred from the claim text.