Ocular therapy with homologous macrophages
AssigneeThe Regents of the University of California
InventorsJorge A. Alvarado, Collin G. Murphy, Johnnie L. Hu
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Abstract
The treatment of glaucoma and other conditions relating to diseased trabecular meshwork in the eye is effected by administration of macrophages and/or cytokines to the eye. Increased levels of macrophages within the anterior chamber of the eye will at least partially clear obstruction of the trabecular meshwork and restore viability of trabecular cells in order to enhance release of aqueous fluid from the anterior chamber and reduce intraocular pressures. The administration of cytolines will either recruit macrophages or will effect repair of the trabecular meshwork cells directly.
Claims6
A method for treating glaucoma in a patient, said method comprising introducing macrophages obtained from the patient to the anterior chamber of an eye of the patient in an amount effective to lower intraocular pressure by clearance of particulate matter from and restoration of aqueous outflow through the trabecular meshwork and to lower intraocular pressure.
A method for treating a condition selected from the group consisting of pigmentary glaucoma and primary open-angle glaucoma in a patient, said method comprising introducing an effective amount of macrophages obtained from the patient into the anterior chamber of the eye of the patient.
Dependencies are inferred from the claim text.