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AssigneesNycomed Imaging AS, Daiichi Pharmaceutical Co., Ltd.
InventorsJo Klaveness, Arne Berg, Trond Vegard Jacobsen, Pal Rongved, Thorfinn Ege, Hiroshi Kikuchi, Kiyoto Yachi
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The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
An autoclaved diagnostic composition for administration to human or animal subjects, said composition containing multilamellar liposomes, optionally together with unilamellar liposomes, said liposomes containing an aqueous phase containing at least one X-ray or magnetic resonance imaging contrast agent, said liposomes being suspended in an aqueous medium containing said contrast agent, said liposomes comprising a neutral phospholipid and a charged phospholipid, the average particle diameter of said liposomes being 50-3000 nm, the concentration of said contrast agent in said aqueous phase being substantially the same as that in the aqueous medium in which said liposomes are suspended during the autoclaving process, and the concentration of total lipid in said composition being 50 mg/mL to 80 mg/mL.
Dependencies are inferred from the claim text.