Lithium and amine dissolving metal reduction
AssigneeAllergan, Inc.
InventorsLloyd J. Dolby, Nestor A. Fedoruk, Shervin Esfandiari, Natalie C. Chamberlain, Michael E. Garst
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Abstract
The invention is directed to a process for reducing or reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at least two amino groups, selected from the group consisting of primary and secondary amino groups and mixtures thereof, e.g. ethylenediamine and R--NH.sub.2, optionally containing a lower alkyl alcohol, wherein R is chosen from the group consisting of ethyl, propyl, and butyl, including all straight and branched chain isomers thereof, for a time sufficient to effect reduction.
Claims35
In a process of reducing an organic compound susceptible to dissolving metal reduction which comprises exposing the organic compound to a solution of lithium in a lower alkyl amine the improvement which comprises providing in such solution a polyamine, including at least two amino groups and selected from the group consisting of primary and secondary amino groups and mixtures thereof, wherein said polyamine comprises from 2 to 4 nitrogen atoms and from 2 to about 30 carbon atoms and R--NH.sub.2, wherein R is chosen from the group consisting of lower alkyl radicals, having from 2 to 6 carbon atoms, including all straight and branched chain isomers thereof, optionally containing a lower alkyl alcohol, for a time sufficient to effect reduction.
A process of reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at least two amino groups, selected from the group consisting of primary and secondary amino groups and mixtures thereof, wherein said polyamine comprises from 2 to 4 nitrogen atoms and from 2 to about 30 carbon atoms, and R--NH.sub.2, wherein R is chosen from the group consisting of lower alkyl radicals, having from 2 to 6 carbon atoms including all straight and branched chain isomers thereof, optionally containing a lower alkyl alcohol, for a time sufficient to effect reductive cleavage.
Dependencies are inferred from the claim text.