Process for preparing aromatic amide compound
AssigneeSumitomo Chemical Company, Limited
InventorsEtsuko Fukuda, Atsushi Furutani, Hideki Ushio, Hirokazu Murata
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Abstract
3-4-(4-Phenyl-1-butoxy)benzoyl!amino-2-hydroxyacetophenone is prepared by reacting a benzoate ester with a halobutylbenzene in the presence of a basic compound and an aprotic polar compound in an aromatic hydrocarbon solvent to obtain a corresponding ether, alkali hydrolyzing the ether in an aromatic hydrocarbon solvent and precipitating a hydrolysate with an acid to obtain 4-(4-phenyl-1-butoxy)benzoic acid, reacting a halogenating agent with this benzoic acid derivative in an aromatic hydrocarbon solvent to obtain an acid halide, and reacting the acid halide in an aromatic hydrocarbon solvent with a corresponding aromatic amine.
Claims8
A process for preparing a compound of the formula (1):
- ##STR9## comprising the steps of:
- reacting a benzoate of the formula (2):
- ##STR10## wherein R is a straight or branched lower alkyl group and a haloalkylbenzene of the formula (3):
- ##STR11## wherein X.sup.1 is a halogen atom in the presence of a basic compound and an aprotic polar compound in an aromatic hydrocarbon solvent to obtain an ether of the formula (4):
- ##STR12## wherein R is the same as defined above, alkali hydrolyzing said ether (4) in an aromatic hydrocarbon solvent and precipitating a hydrolysate with an acid to obtain a benzoic acid derivative of the formula (5):
- ##STR13## reacting said benzoic acid derivative (5) in an aromatic hydrocarbon solvent with a halogenating agent to obtain an acid halide of the formula (6):
- ##STR14## wherein X.sup.2 is a halogen atom, and reacting said acid halide (6) in an aromatic hydrocarbon solvent with an aromatic amine of the formula (7):
- ##STR15##
A process for preparing an ether of the formula (4):
- ##STR16## wherein R is a straight or branched lower alkyl group, comprising reacting a benzoate of the formula (2):
- ##STR17## R is the same as defined above, and a haloalkylbenzene of the formula (3):
- ##STR18## wherein X.sup.1 is a halogen atom in the presence of a basic compound and an aprotic polar compound in an aromatic hydrocarbon solvent.
Dependencies are inferred from the claim text.