Oligonucleotides specific for cytokine signal transducer gp130 mRNA
AssigneeGen-Probe Incorporated
InventorsKathleen Ann Becherer, Nanibhushan Dattagupta, Yathi M. Naidu
Life of this patent
Estimating the term…
Abstract
The present invention relates to oligonucleotides which are effective inhibitors of disease-associated cellular proliferation. In particular, it relates to the use of oligonulceotides which are substantially complementary to gp130 mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
Claims15
An oligonucleotide which inhibits gp 130 production in vitro having a nucleotide sequence selected from the group consisting of:
- SEQ. ID. NO. 1 GCCCAGCGC GACTCCGCGG GCCTT
- SEQ. ID. NO. 2 CCTGTAGATT CAGTGGTGAG
- SEQ. ID. NO. 3 ACACAAACTG CAGTGAAATT AGAATG
- SEQ. ID. NO. 4 TACATGAAAA TAATCCATAC ATT
- SEQ. ID. NO. 5 GTTTATGATA GTATATTGCT CCTTA
- SEQ. ID. NO. 6 CCATAAACATT CTGTTCAAGC TGTC
- SEQ. ID. NO. 7 TGCCCATTCA GATTTTAAAG TGAAG
- SEQ. ID. NO. 8 GCTTTGCAAT CAGCAAACTT GTGTGT
- SEQ. ID. NO. 9 TACAGGATCA AAATTGATAT GATCTGATGT AACC
- SEQ. ID. NO. 10 GGCATCTTTG GTCCTATATT G
- SEQ. ID. NO. 11 AGGATCTGGA ACATTAGGC, and
- SEQ. ID. NO. 12 GCTCGAAGTG TTTTGTGAAG.
Dependencies are inferred from the claim text.