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US 5,674,981 AGranted
Human calcitonin receptor polypeptides
AssigneeZymoGenetics, Inc.
InventorsEmma E. Moore, Paul O. Sheppard, Rolf E. Kuestner
Life of this patent
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Abstract
Human calcitonin receptors have been cloned, sequenced and expressed by recombinant means. The receptors and antibodies thereto may be used in screening systems to identify agonists and antagonists of human calcitonin receptors, thereby providing means for treating and preventing abnormal bone resorption, as well as in methods of diagnosis.
Claims7
A purified human calcitonin receptor polypeptide having (a) the amino acid sequence shown in SEQ ID NO:
- 2, (b) the amino acid sequence shown in SEQ ID NO:
- 25, (c) the amino acid sequence of a naturally occurring allelic variant of (a) or (b), or (d) a N-terminal ligand-binding domain, a first transmembrane domain, and a first intracellular domain of (a), (b), or (c).
Dependencies are inferred from the claim text.