Peptides derived from glutamic acid decarboxylase
AssigneeThe Regents of the University of California
InventorsAllan J. Tobin, Mark G. Erlander, Daniel L. Kaufman, Michael J. Clare-Salzler
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Abstract
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.
Claims8
A composition comprising a peptide consisting of an amino acid sequence selected from the group consisting of
- KPCSCSKVDVNYAFLHATDL;
- TAGTTVYGAFDPLLAVADICKK;
- EYLYNIIKNREGYEMVFDGK;
- IPPSLRTLEDNEERMSRLSK;
- SRLSKVAPVIKARMMEYGTT;
- EYGTTMVSYQPLGDKVNFFR;
- ATHQDIDFLIEEIERLGQDL;
- LAFLQDVMNILLQYVVKSFDRS;
- EEILMHCQTTLKYAIKTGHP;
- DERGKMIPSDLERRILEAKQ;
- KHYDLSYDTGDKALQCGRHV;
- AALGIGTDSVILIKCDERGK;
- GLLMSRKHKWKLSGVERANS;
- LEAKQKGFVPFLVSATAGTT;
- and
- VNFFRMVISNPAATHQDIDF.
A composition comprising peptides having the sequence DERGKMIPSDLERRILEAKQ, AALGIGTDSVILIKCDERGK, and GLLMSRKHKWKLSGVERANS.
A composition comprising a polypeptide of from 5 to 12 amino acids in length consecutively contained within a sequence selected from the group consisting of
- KPCSCSKVDVNYAFLHATDL;
- TAGTTVYGAFDPLLAVADICKK;
- EYLYNIIKNREGYEMVFDGK;
- IPPSLRYLEDNEERMSRLSK;
- SRLSKVAPVIKARMMEYGTT;
- EYGTTMVSYQPLGDKVNFFR;
- ATHQDIDFLIEEIERLGQDL;
- LAFLQDVMNILLQYVVKSFDRS;
- EEILMHCQTTLKYAIKTGHP;
- DERGKMIPSDLERRILEAKQ;
- KHYDLSYDTGDKALQCGRHV;
- AALGIGTDSVILIKCDERGK;
- GLLMSRKHKWKLSGVERANS;
- LEAKQKGFVPFLVSATAGTT;
- and
- VNFFRMVISNPAATHQDIDF,
- wherein said polypeptide binds to an HLA or autoantibody related to IDDM.
A composition comprising a polypeptide of from 5 to 12 amino acids in length consecutively contained within a sequence selected from the group consisting of
- KPCSCSKVDVNYAFLHATDL;
- TAGTTVYGAFDPLLAVADICKK;
- EYLYNIIKNREGYEMVFDGK;
- IPPSLRYLEDNEERMSRLSK;
- SRLSKVAPVIKARMMEYGTT;
- EYGTTMVSYQPLGDKVNFFR;
- and
- ATHQDIDFLIEEIERLGQDL,
- wherein said polypeptide binds to an HLA or autoantibody related to IDDM.
Dependencies are inferred from the claim text.