Transgenic mice expressing the neurotoxic C-terminus of .beta.-amyloid precursor protein
AssigneeThe Regents of the University of California
InventorRachael L. Neve
Life of this patent
Estimating the term…
Abstract
The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an amyloid-containing polypeptide fragment of amyloid precursor protein, through the introduction of the DNA into the germ and somatic cells of the animal by transgenic methods.
Claims8
A transgenic mouse whose somatic and germ cells contain a transgene encoding an about 100 amino acid neurotoxic C-terminal fragment of the .beta.-amyloid precursor protein, wherein said transgene is operably linked to a brain tissue promoter, and wherein expression of said transgene results in the formation of punctate deposits in neuronal processes of the mouse's brain.
Dependencies are inferred from the claim text.