Method of producing racemic amino alcohols
AssigneeDegussa AG
InventorsKarlheinz Drauz, Wilfried Jahn, Michael Schwarm
Life of this patent
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Abstract
.alpha.-oximino carboxylic acids or their esters are reduced with an alkali boron hydride and hydrogen chloride or sulfuric acid to yield racemic amino alcohols (e.g. (RS)-tert-leucinol).
Claims10
A method of producing racemic amino alcohols of general formula I ##STR4## wherein R1 is a straight-chain, branched or cyclic alkyl-, arylalkyl- or aryl group with up to 20C atoms, comprising reducing .alpha.-oximino carboxylic acids or their esters of general formula III ##STR5## wherein R1 has the meaning indicated above and R2 stands for hydrogen or an alkyl group with up to four C atoms, wherein reduction is carried out with an alkali boron hydride in conjunction with hydrogen chloride or sulfuric acid as activator in a solvent.
Dependencies are inferred from the claim text.