Process for producing .alpha.-(trifluoromethyl)arylacetic acid
AssigneeNippon Mektron, Ltd.
InventorsTakehiro Sonoi, Futoshi Masaki, deceased, Toshio Kubota
Life of this patent
Estimating the term…
Abstract
.alpha.-(trifluoromethyl)arylacetic acid for use as raw materials for medicines, agricultural chemicals, liquid crystals etc. or reagents for determining an optical purity is readily obtained through very simple reaction steps, i.e. by reacting a perfluoro(2-methyl-1,2-epoxypropyl)ether compound obtainable by ozone, oxidation of a heptafluoroisobutenyl ether compound with an aromatic compound ArH to afford an .alpha.,.alpha.-bis(trifluoromethyl)arylacetic acid ester, followed by decarboxylation and hydrolysis of the resulting ester compound.
Claims5
A process for producing .alpha.-(trifluoromethyl)arylacetic acid, represented by the following general formula:
- ##STR12## wherein Ar is an aryl group, which comprises subjecting an .alpha.,.alpha.-bis(trifluoromethyl)arylacetic acid ester, represented by the following general formula:
- ##STR13## wherein Ar has the same meaning as defined above and R is a lower alkyl group, an aryl group or a benzyl group, to reaction with a base in the presence of water.
Dependencies are inferred from the claim text.