Process for manufacturing cephem derivatives

Abstract

The objective of this invention is to provide a process of manufacturing cephem derivatives expressed by the following formula (1), wherein the compound (2) is reacted with an condensing agent of the compound (4) and 1-hydroxy-6-trifluoromethyl benzotriazole(5) and the mixture is acylated with 7-aminocephosporanic acid (3) or its derivatives. ##STR1## According to this invention, a desirous product with high purity may be obtained, which is more cost-saving and industrially feasible than the conventional methods, under the following process steps: Without protecting amino group of organic acid (2), conversion of the reactive derivatives under mild temperature is made and the acylation is directly carried out to obtain the final product.

Dependencies are inferred from the claim text.