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US 5,672,705 AGranted
Imidazo (1,2-A)pyrazine-4-one derivatives/useful as antagonists of AMPA and NMDA receptors
AssigneeRhone-Poulenc Rorer S.A.
InventorsJean-Claude Aloup, Serge Mignani
Life of this patent
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Abstract
Compounds of formula (I), wherein R is an oxygen or sulphur atom or an NH or N-alk radical, and each of R.sub.1 and R.sub.2, which are the same or different, is a hydrogen or halogen atom or an alkyl, alkoxy, amino, acylamino, --NH--CO--NH--Ar,--N.dbd.CH--N(alk)alk', nitro, cyano, phenyl, imidazolyl or SO.sub.3 H radical, the preparation thereof, and drugs containing such compounds, are disclosed.
Claims5
A compound of formula (I) or a salt thereof:
- ##STR11## in which R represents an oxygen or sulphur atom, or an NH or N-alk radical,
- R.sub.1 and R.sub.2, which are identical or different, each represents hydrogen, a halogen atom, an alkyl, alkoxy, amino, acylamino, --NH--CO--NH--Ar, --N.vertline.CH--N(alk)alk', nitro, cyano, phenyl, imidazolyl or SO.sub.3 H radical,
- Ar represents a phenyl radical,
- said alkyl and alkoxy radicals containing from 1 to 4 carbon atoms in a straight or branched chain, and said acyl portions containing from 2 to 5 carbon atoms;
- including isomers or mixtures of isomers of the compounds of formula (I) when R.sub.1 and/or R.sub.2 represent an --N.vertline.CH--N(alk)alk' radical.
2 more elements
Dependencies are inferred from the claim text.