Transferrin neuropharmaceutical agent fusion protein
AssigneesAlkermes, Inc., The Regents of the University of California
InventorsPhillip M. Friden, Ruth M. Starzyk, Sherie L. Morrison, Eun-Chung Park
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Abstract
The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of a ligand-neuropharmaceutical agent fusion protein wherein the ligand is reactive with a brain capillary endothelial cell receptor. Other aspects of this invention include a delivery system comprising a ligand reactive with a brain capillary endothelial cell receptor which has formed a fusion protein with a neuropharmaceutical agent. The fusion proteins are also aspects of this invention.
Claims11
A fusion protein comprising transferrin at the carboxyl terminus linked to a neuropharmaceutical agent at the amino terminus, wherein said neuropharmaceutical agent is either nerve growth factor (NGF) or ciliary neurotrophic factor (CNTF).
Dependencies are inferred from the claim text.