US 5,672,627 A · Substituted spirodienes for the treatment of inflammation

Abstract

A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein R.sup.8 is selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy, butoxy, hydroxyl, mercapto, methylthio, ethylthio, cyano, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, trifluoromethoxy, hydroxymethyl, methoxymethyl and ethoxymethyl; or a pharmaceutically-acceptable salt thereof.

Claims29

Dependent claims

A compound of Formula II ##STR31## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido;

wherein R.sup.3 is methylsulfonyl or sulfamyl;
wherein each of R.sup.6 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto;
and wherein n is 0;
or a pharmaceutically-acceptable salt thereof.

1 more element

Compound of claim 41 wherein n is 0;

and wherein each of R.sup.6 through R.sup.10 is independently selected from hydrido, halo, lower alkyl, lower alkylthio, cyano, lower haloalkyl, lower haloalkoxy, lower alkoxy, hydroxyl, mercapto, lower hydroxyalkyl, and lower alkoxyalkyl;
or a pharmaceutically-acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

08/677,263Filed 9 Jul 1996 · continuation

Priority

4 May 1994

Granted

30 Sep 1997

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07C 317/44
Sulfones; Sulfoxides: having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
C07C 311/16
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings: having the nitrogen atom of at least…
C07C 311/29
Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms: having the sulfur atom of at least one…
C07C 317/14
Sulfones; Sulfoxides: having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings

Substituted spirodienes for the treatment of inflammation

Life of this patent

Substituted spirodienes for the treatment of inflammation

Life of this patent

Abstract

Claims29