Substituted spirodienes for the treatment of inflammation
AssigneeG. D. Searle & Co.
InventorsHorng-Chih Huang, David R. Reitz
Life of this patent
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Abstract
A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido; wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein each of R.sup.6 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto; and wherein n is 1, 2 or 3; or a pharmaceutically-acceptable salt thereof.
Claims18
A compound of Formula I ##STR31## wherein A is selected from ##STR32## wherein each of R.sup.1 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl, haloalkylsulfonyl and sulfamyl;
- and wherein n is a number selected from 0, 1, 2 and 3;
- or a pharmaceutically-acceptable salt thereof.
A compound of Formula II ##STR33## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido;
- wherein R.sup.3 is methylsulfonyl or sulfamyl;
- and wherein each of R.sup.6 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto;
- and wherein n is 1, 2 or 3;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.