Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock
AssigneeBayer Aktiengesellschaft
InventorsPeter Wachtler, Lutz Heuer, Martin Kugler, Heinrich Schrage
Life of this patent
Estimating the term…
Abstract
This application relates to new thiocarbamoyl compounds of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the description.
Claims13
A thiocarbamoyl compound of the formula ##STR353## in which R.sup.1, R.sup.2 and R.sup.3 in each case independently of one another represent hydrogen or methyl and
- R.sup.4 represents cyclopentyl
- n represents the number 1
- or a metal salt complex or an acid addition product thereof.
A process for the preparation of a compound of ##STR354## R.sup.1, R.sup.2 and R.sup.3 in each case independently of one another represent hydrogen or methyl and
- R.sup.4 represents cyclopentyl, cyclopentenyl, or cyclohexenyl,
- which comprises reacting a formyl acid derivative of the formula ##STR355## wherein R.sup.3 and R.sup.4 are defined above and R represents methyl, ethyl, n- or i-propyl or n-, i-, s- or t-butyl, with a thiosemicarbazido of the formula
- NH.sub.2 --NH--CS--NR.sup.1 R.sup.2 (III)
- optionally in the presence of a diluent or solvent and a base.
A thiocarbamoyl compound of the formula ##STR356## in which R.sup.1, R.sup.2 and R.sup.3 in each case independently of one another represent hydrogen or methyl and
- R.sup.4 represents cyclopentenyl or cyclohexenyl,
- n represents 0 or 1
- or a salt or metal complex thereof.
A process for the protection of industrial materials against attack or destruction by undesired microorganism which comprises applying or mixing a compound of the formula ##STR359## in which R.sup.1, R.sup.2 and R.sup.3 in each case independently of one another represent hydrogen or methyl,
- R.sup.4 represents cyclohexyl,
- n represents 1,
- or a metal salt complex or an acid addition salt thereof.
Dependencies are inferred from the claim text.