US 5,672,607 A · Antiviral naphthoquinone compounds, compositions and uses thereof

Abstract

The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Claims24

Dependent claims

An antiviral naphthoquinone, in substantially pure form, selected from the group consisting of:

##STR4## wherein each of R.sub.1 -R.sub.12 is the same or different, and each is H, a C.sub.1 -C.sub.10 straight-chain or branched-chain saturated or unsaturated alkyl, an aryl, OCH.sub.3, or OH.

Dependencies are inferred from the claim text.

Facts

Application

08/011,183Filed 29 Jan 1993

Granted

30 Sep 1997

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

C07D 311/92
Ring systems having three or more relevant rings: naphthopyrans; Hydrogenated naphthopyrans
A61K 31/12
Medicinal preparations containing organic active ingredients: ketones
A61K 31/35
Having oxygen as the only ring hetero atom, e.g. fungichromin: having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/352
Having six-membered rings with one oxygen as the only ring hetero atom: condensed with carbocyclic rings, e.g. methantheline

Antiviral naphthoquinone compounds, compositions and uses thereof

Life of this patent

Antiviral naphthoquinone compounds, compositions and uses thereof

Life of this patent

Abstract

Claims24