Apoptosis regulating composition
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsSatoru Nakai, Koutoku Aihara, Hitomi Mori, Michiaki Tominaga, Masakazu Adachi, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito
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Abstract
An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.
Claims6
A method for regulating apoptosis in a host in need of such regulation which comprises administering to said host an apoptosis regulating effective amount of at least one carbostyril derivative represented by general formula (1) or a salt thereof:
- ##STR3## wherein R is a benzoyl group which may optionally be substituted with a lower alkoxy group on the phenyl ring, and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond.
A method for treatment of cancer which comprises administering to a host afflicted with cancer an anti-cancer effective amount of at least one carbostyril derivative represented by general formula (1) or a salt thereof:
- ##STR4## wherein R is a benzoyl group which may optionally be substituted with a lower alkoxy group on the phenyl ring, and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond.
A method for inhibiting tumor metastasis which comprises administering to a host afflicted with metastatic tumors an anti-tumor effective amount of at least one carbostyril derivative represented by general formula (1) or a salt thereof:
- ##STR5## wherein R is a benzoyl group which may optionally be substituted with a lower alkoxy group on the phenyl ring, and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond.
Dependencies are inferred from the claim text.