3-8-diazabicyclo ›3.2.1! octane derivatives having analgesic activity

Abstract

Compounds of general formula (I) ##STR1## wherein R and R.sub.1, different from each other, are a straight or branched C.sub.2 -C.sub.8 acyl group; a group of formula --CH.sub.2 -- (A)--B wherein: A is a single bond between two carbon atoms, or a group of formula --CH--CH, --CH.sub.2 --CO--, B is a C.sub.6 -C.sub.10 aryl group, optionally substituted, at the ortho-meta- and para-positions, with one or more substituents, which are the same or different, selected from the group consisting of CONHR, carboxyl, cyano, nitro, NHCOR; an aromatic heterocyclic or alicyclic group with 5 or 6 members in the ring, optionally benzocondensed, having at least one heteroatom selected from nitrogen, oxygen, sulfur, said heterocyclic group optionally having one or more substituents as described above for the aryl group; with the proviso that when one of R or R.sub.1 is the propionyl group, the other can not be the cinnamyl group or the p-nitrocinnamyl group, and when R is the propionyl group, R.sub.1 cannot be o-, or m-nitrocinnamyl; and the pharmaceutically acceptable salts thereof. Compounds of formula (I) have central analgesic activity.

Dependencies are inferred from the claim text.