Compounds containing a fused bicycle ring

A compound of the formula ##STR85## or a pharmaceutically acceptable salt thereof wherein:

• ##STR86## X is O or S--(O).sub.t ;
• R.sub.1 and R.sub.12 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, substituted alkyl, substituted alkenyl, aryl, substituted aryl, heteroaryl, cycloalkyl-alkylene-, aryl-alkylene-, substituted aryl-alkylene-, and heteroaryl-alkylene- or R.sub.1 and R.sub.12 taken together with the carbon to which they are attached complete a cycloalkyl ring or a benzofused cycloalkyl ring;
• R.sub.2 is hydrogen, ##STR87## or R.sub.11 --S--;
• R.sub.3, R.sub.5 and R.sub.7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl-(CH.sub.2).sub.p --, substituted aryl-(CH.sub.2).sub.p --, heteroaryl-(CH.sub.2).sub.p --, ##STR88## R.sub.4 is alkyl, cycloalkyl-(CH.sub.2).sub.p --, substituted alkyl, aryl-(CH.sub.2).sub.p --, substituted aryl-(CH.sub.2).sub.p --, or heteroaryl-(CH.sub.2).sub.p --;
• R.sub.6 is alkyl, substituted alkyl, cycloalkyl-(CH.sub.2).sub.p --, aryl-(CH.sub.2).sub.p --, substituted aryl-(CH.sub.2).sub.p --, or heteroaryl-(CH.sub.2).sub.p --;
• R.sub.8 is hydrogen, lower alkyl, cycloalkyl, or phenyl;
• R.sub.9 is hydrogen, lower alkyl, lower alkoxy, or phenyl;
• R.sub.10 is lower alkyl or aryl-(CH.sub.2).sub.p --;
• R.sub.11 is hydrogen, alkyl, substituted alkyl, cycloalkyl-(CH.sub.2).sub.p --, aryl-(CH.sub.2).sub.p --, substituted aryl-(CH.sub.2).sub.p --, heteroaryl-(CH.sub.2).sub.p --, or --S--R.sub.11 completes a symmetrical disulfide wherein R.sub.11 is ##STR89## m is zero or one;
• Y is CH.sub.2, S--(O).sub.t or O provided that Y is S--(O).sub.t or O only when m is one;
• n is one;
• p is zero or an integer from 1 to 6;
• q is zero or an integer from 1 to 3;
• r is zero or one;
• and
• t is zero, one, or two.