Acetamide derivative
AssigneeKaken Pharmaceutical Co., Ltd.
InventorsNobuo Ishiyama, Toshihiro Koyama, Mitsuo Hayashida, Katsuyuki Otsuka, Masahiro Fujii, Kunio Kimura, Yoshiyuki Hata, Nobuko Miyao
Life of this patent
Estimating the term…
Abstract
An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating agent for peptic ulcer and for gastritis which comprises the above-mentioned compound having the general formula (I) as an effective ingredient, and a process for treating peptic ulcer and gastritis using the above-mentioned compound having the general formula (I), are disclosed.
Claims7
An acetamide derivative having the general formula (I):
- ##STR162## wherein each of R.sup.1 and R.sup.2 is a C.sub.1-7 alkyl group, or R.sup.1 and R.sup.2 taken together join to form the formula --(CH.sub.2).sub.m -- wherein m is 4 to 6,
- R.sup.3 is hydrogen atom, a halogen atom, a C.sub.1-7 alkyl group, a C.sub.1-4 alkoxy group, nitro group, amino group, cyano group, carboxyl group or acetyl group, which may be substituted for any hydrogen atom of the ring,
- X is --CH.sub.2 -- or --CH.dbd.CH--,
- n is 0 or 1,
- Y is oxygen atom, sulfur atom or .dbd.N--CN,
- Z is CH or nitrogen atom, and
- R.sup.0 is R.sup.4, --NHR.sup.5 or --OR.sup.6, wherein each of R.sup.4, R.sup.5 and R.sup.6 is hydrogen atom;
- a C.sub.1-7 alkyl group;
- a C.sub.2-6 alkenyl group;
- a C.sub.2-6 alkynyl group;
- a C.sub.1-4 alkoxy C.sub.1-7 alkyl group;
- a C.sub.1-5 acyloxy C.sub.1-7 alkyl group;
- a C.sub.7-16 aralkyl group;
- a phenyl or a heterocyclic group which may be substituted by a C.sub.1-7 alkyl group, a halogen atom, a C.sub.1-4 alkoxy group, nitro group, trifluoromethyl group, amino group, cyano group, carboxyl group or acetyl group;
- a C.sub.1-7 alkyl group substituted by a heterocycle,
- or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.