Purine derivatives
AssigneeNovo Nordisk A/S
InventorsLars Jacob Stray Knutsen, Jesper Lau
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Abstract
A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is hydrogen, amino, halogen, hydroxy, lower alkoxy or lower alkyl and R.sup.1 is ##STR2## wherein Y is methylene or a valence bond, R.sup.2 and R.sup.5 is H or lower, straight or branched alkyl, R.sup.3 is H or lower alkyl, or R.sup.2 and R.sup.3 can together form a cyclobutyl, cyclopentyl, cyclohexyl or phenyl ring, Z is oxygen, methylene, sulphur, sulphonyl or a valence bond, R.sup.4 is H, lower alkyl, aralkyl, a mono or bicyclic aromatic system optionally substituted with various groups. The compounds have been found useful for treating central nervous system ailments.
Claims12
A method of treating epilepsy in a person in need thereof, comprising administering an effective amount of a compound, wherein the compound is selected from the group consisting of:
- 2-chloro-N-(1-phenoxy-2-propyl)adenosine;
- 2-chloro-N-(R)-1-phenoxy-2-propyl!adenosine;
- 2-chloro-N-(2-phenoxyethyl)adenosine;
- 2-chloro-N-(1-phenyl-3-butyl)adenosine;
- 2-amino-N-(1-phenoxy-2-propyl)adenosine;
- 2-chloro-N-(cis-2-phenoxycyclopentyl)adenosine;
- 2-chloro-N-(trans-2-phenoxycyclopentyl)adenosine;
- 2-chloro-N-(R)-1-phenylthio-2-propyl!adenosine;
- (R)-2-chloro-N-1-(4-fluorophenoxy)-2-propyl!adenosine;
- 2-methoxy-N-(R)-1-phenoxy-2-propyl!adenosine;
- 2-methyl-N-(R)-1-phenoxy-2-propyl!adenosine;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.