US 5,672,511 AGranted

Base-modified enzymatic nucleic acid

AssigneeRibozyme Pharmaceuticals, Inc.

InventorsLeonid Beigelman, Alex Karpeisky

Life of this patent

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Abstract

Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.

Claims17

Dependent claims

An enzymatic nucleic acid molecule comprising at least one modified nucleotide, wherein base portion of said modified nucleotide is a 6-methyl uracil.

Dependencies are inferred from the claim text.

Facts

Application: 08/437,114Filed 5 May 1995 · division
Priority: 15 Oct 1992
Granted: 30 Sep 1997
Term ends: Not estimatedThe source records don’t support an estimate.

Classification38 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
C07H 19/06
Heterocyclic radicals containing only nitrogen atoms as ring hetero atom: pyrimidine radicals
C07H 19/10
Pyrimidine radicals: with the saccharide radical esterified by phosphoric or polyphosphoric acids
C07H 19/16
Heterocyclic radicals containing only nitrogen atoms as ring hetero atom: purine radicals

Family

Serial963,322Parent of this continuation-in-part · filed 15 Oct 1992
Serial149,210Parent of this continuation-in-part · filed 8 Nov 1993
Serial363,254Parent of this division · filed 23 Dec 1994
US 5,672,511 AThis patent

From the US filing history. Foreign family members aren’t listed.

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