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AssigneeDaicel Chemical Industries, Ltd.
InventorsAkinobu Matsuyama, Yoshinori Kobayashi
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A microorganism or a preparation thereof is permitted to act on a mixture of enantiomers of an epoxide such as 3-chlorostyrene oxide and the product optically active epoxide is recovered. The microorganism able to produce an optically active (S)-epoxide from the mixture of enantiomers of the epoxide include, for example, a microorganism strain belonging to the genus Candida, the genus Rhodosporidium, the genus Rhodococcus and the genus Nosardioides. Examples of the microorganism capable of producing an optically active (R)-epoxide from said mixture include a microorganism strain belonging to the genus Trichosporon, the genus Geotrichum, the genus Corynebacterium, the genus Micrococcus and the genus Brevibacterium. The objective optically active epoxide can efficiently be obtained with ease and simplicity from the corresponding mixture of enantiomers of the epoxide.
A process for enriching or preferentially increasing the concentration of the (S)-enantiomer of the epoxide of formula (I) in an enantiomeric mixture of (R,S)-epoxide of formula (I) ##STR2## comprising:
A process for enriching or preferentially increasing the concentration of the (R)-enantomer of the epoxide of formula (I) in an enantiomeric mixture of (R,S)-epoxide of formula (I) ##STR3## comprising:
The process according to claim l or 2, wherein the enantiomeric mixture is a racemic mixture.
Dependencies are inferred from the claim text.