Base-modified enzymatic nucleic acid
AssigneeRibozyme Pharmaceuticals, Inc.
InventorsJasenka Matulic-Adamic, Leonid Beigelman, Nassim Usman, Alex Karpeisky, Alex Burgin
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Abstract
An enzymatic nucleic acid having a modification selected from pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, 6-methyl-uracil and aminophenyl.
Claims16
An enzymatic nucleic acid molecule comprising at least one modified nucleotide base substitution, wherein the base portion of said nucleotide is selected from the group consisting of pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, and aminophenyl.
An enzymatic nucleic acid molecule comprising at least two modified nucleotide base substitutions, wherein the base portion of said nucleotide is selected from the group consisting of pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, and aminophenyl, wherein said nucleotide base substitution is same or different.
Dependencies are inferred from the claim text.