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US 5,672,372 AGranted
Method for sweetening a food composition with single-chain monellin analogs
AssigneesThe Regents of the University of California, Lucky Biotech Corp.
InventorsSung-Hou Kim, Joong Myung Cho
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Abstract
Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.
Claims11
A method to provide a sweet flavor to a food composition which comprises including a sweetness enhancing amount of, in said composition a single chain sweet proteinaceous compound of the formula B-C-A,
- wherein B represents a peptide portion at least 90% homologous to residues 1-46 of the B chain of native monellin and modified only by conservative substitutions;
- C is a covalent bond or is a hydrophilic, physiologically acceptable covalent linker capable of providing a spacing length equivalent to a peptide of 1-10 amino acids selected so as to reside on the external portion of the molecule and not to disturb the native conformation;
- and
- A represents a peptide at least 90% homologous to residues 6-45 of the A chain of native monellin and modified only by conservative substitution.
1 more element
Dependencies are inferred from the claim text.