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US 5,672,361 AGranted
Laminin 5 for growth of pancreatic islet cells
AssigneeDesmos, Inc.
InventorsCraig Halberstadt, John J. Grzesiak
Life of this patent
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Abstract
A method of expanding the number of pancreatic islet cells for transplantation. Fetal islet cells are cultured in the presence of laminin 5 extracellular matrix, resulting in a significant increase in cell number after passaging in culture. The expanded islet cells contain insulin and respond to glucose challenge.
Claims13
A method of growing cells of pancreatic islet-like cell clusters (ICCs), comprising the step of culturing said ICCs in culture media in contact with laminin 5, with the proviso that said laminin 5 is not rat laminin 5.
Dependencies are inferred from the claim text.