Kit for the diagnosis of insulin dependent diabetes mellitus
AssigneeYeda Research and Development Co. Ltd.
InventorsIrun Robert Cohen, Dana Elias, Doron Markovits
Life of this patent
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Abstract
A 65 KD heat shock protein, proteins cross-reactive therewith, or antibodies thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof.
Claims13
A kit for diagnosing the presence or incipience of IDDM, comprising:
- hHSP65;
- a tagged antibody capable of recognizing the non-variable region of the anti-hHSP65 antibody to be detected;
- and
- means for conveying to the user that the kit is for use in the diagnosis of IDDM.
A kit for diagnosing the presence or incipience of IDDM, comprising:
- antibodies reactive or cross-reactive with a first epitope of hHSP65;
- a tagged antibody capable of recognizing an epitope of hHSP65 other than said first epitope;
- and
- means for conveying to the user that the kit is for use in the diagnosis of IDDM.
A kit for diagnosing the presence or incipience of IDDM, comprising:
- hsp65;
- a tagged antibody capable of recognizing the non-variable region of the antibody to be detected;
- and
- means for conveying to the user that the kit is for use in the diagnosis of IDDM.
Dependencies are inferred from the claim text.