Process for the production of an improved form of form 1 ranitidine
AssigneeBrantford Chemicals Inc.
InventorKeshava Murthy
Life of this patent
Estimating the term…
Abstract
Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding anhydrous hydrogen chloride gas to Ranitidine free base wherein said substantially anhydrous hydroxylic solvent has the characteristics that it solubilizes the Ranitidine free base and hydrogen chloride gas, and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.
Claims22
Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics and having:
- (i) a bulk density of not less than about 0.23 gm/ml;
- and,
- a tap density of not less than about 0.28 gm/ml,
- said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding anhydrous hydrogen chloride gas to Ranitidine free base wherein said substantially anhydrous hydroxylic solvent has the characteristics that it solubilizes the Ranitidine free base and hydrogen chloride gas, and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.
Process for the production of a improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics and having:
- (i) a bulk density of not less than about 0.23 gm/ml;
- and,
- (ii) a tap density of not less than about 0.28 gm/ml,
- said process comprising adding Ranitidine Hydrochloride to a substantially anhydrous hydroxylic solvent comprising at least one alkanol having 3-4 carbon atoms, which has the characteristics that it dissolves Ranitidine Hydrochloride and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.
Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics and having:
- (i) a bulk density of not less than about 0.23 gm/ml;
- and,
- (ii) a tap density of not less than about 0.28 gm/ml,
- said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding anhydrous hydrogen chloride gas to Ranitidine free base wherein said substantially anhydrous hydroxylic solvent has the characteristics that it solubilizes the Ranitidine free base and hydrogen chloride gas, heating the solution to a temperature of greater than about 40.degree. C. and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.
Process for the production of a improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics and having:
- (i) a bulk density of not less than about 0.23 gm/ml;
- and,
- (ii) a tap density of not less than about 0.28 gm/ml,
- said process comprising adding Ranitidine Hydrochloride to a substantially anhydrous hydroxylic solvent comprising at least one alkanol having 3-4 carbon atoms, which has the characteristics that it dissolves Ranitidine Hydrochloride, heating the solution to a temperature of greater than about 40.degree. C. and subsequently recovering the improved form of Form 1 Ranitidine Hydrochloride.
Dependencies are inferred from the claim text.